Pub. Date : 2016 Sep 16
PMID : 27501757
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells. | celastrol | microRNA 17 | Homo sapiens |
| 2 | In the present study, we demonstrate that the miR-17-92a cluster plays a negative role in celastrol induced-autophagy. | celastrol | microRNA 17 | Homo sapiens |
| 3 | Celastrol induced autophagy was inhibited by miR-20a or miR-17, while the inhibitory effects were rescued in the presence of pcDNA-ATG7 lacking 3" UTR, demonstrating that these two members target ATG7 to inhibit celastrol-induced autophagy. | celastrol | microRNA 17 | Homo sapiens |
| 4 | In summary, our results demonstrate that celastrol downregulates AR and its target miR-17-92a, leading to autophagy induction in prostate cancer cells. | celastrol | microRNA 17 | Homo sapiens |