Title : Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer.

Pub. Date : 2016 Oct

PMID : 27497816






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using a 4T1 breast cancer model, we show that in vivo administration of PX-478, an inhibitor of oxygen-sensitive HIF-1alpha, led to reduced expression of Foxp3 and VEGF transcript and/or protein, molecules that are directly controlled by HIF-1. 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide vascular endothelial growth factor A Mus musculus