Title : Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy.

Pub. Date : 2016 Oct

PMID : 27484637






2 Functional Relationships(s)
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1 Cell viability was reduced by sorafenib from 1 mumol/L in HepG2 or HuH7 cells, and 2.5 mumol/L in Hep3B cells. Sorafenib MIR7-3 host gene Homo sapiens
2 Co-administration of melatonin and sorafenib exhibited a synergistic cytotoxic effect on HepG2 and HuH7 cells, while Hep3B cells displayed susceptibility to doses of sorafenib that had no effect when administrated alone. Sorafenib MIR7-3 host gene Homo sapiens