Title : Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation.

Pub. Date : 2016 Sep

PMID : 27470515






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The mechanism of this effect involves Nef interacting with an ER chaperone calnexin and disrupting calnexin binding to ABCA1, leading to ABCA1 retention in ER, its degradation and resulting suppression of cholesterol efflux. Cholesterol S100 calcium binding protein B Homo sapiens
2 Replacing lysine residues in positions 4 and 7 of Nef with alanines abrogates Nef-calnexin interaction, prevents ABCA1 downregulation by Nef, and preserves cholesterol efflux from HIV-infected cells. Cholesterol S100 calcium binding protein B Homo sapiens