Title : Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.

Pub. Date : 2016 Sep

PMID : 27460676






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Each IMiD binds to CRBN and alters the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins such as Ikaros and Aiolos. ikaros cereblon Homo sapiens
2 Each IMiD binds to CRBN and alters the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins such as Ikaros and Aiolos. ikaros cereblon Homo sapiens