Pub. Date : 2016 Oct
PMID : 27460145
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incubation with Ws-Lynx1 decreases nicotine-mediated extracellular signal-regulated kinase phosphorylation in PC12 cells and striatal neurons, indicating that binding of Ws-Lynx1 is sufficient to inhibit signaling downstream of nAChRs. | Nicotine | Ly6/neurotoxin 1 | Rattus norvegicus |
| 2 | Incubation with Ws-Lynx1 decreases nicotine-mediated extracellular signal-regulated kinase phosphorylation in PC12 cells and striatal neurons, indicating that binding of Ws-Lynx1 is sufficient to inhibit signaling downstream of nAChRs. | Nicotine | Ly6/neurotoxin 1 | Rattus norvegicus |
| 3 | The effect of nicotine in PC12 cells is independent of alpha7 or alpha4beta2 nAChRs, suggesting that Lynx1 can affect the function of native non-alpha7, non-alpha4beta2 nAChR subtypes. | Nicotine | Ly6/neurotoxin 1 | Rattus norvegicus |