Title : Human peripheral lymphocyte growth regulation and response to phorbol esters is linked to synthesis and phosphorylation of the cytosolic protein, prosolin.

Pub. Date : 1989 Aug 1

PMID : 2745978






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In our study we examined the expression of prosolin in human peripheral lymphocytes and investigated the effects of TPA treatment on prosolin phosphorylation and on lymphocyte proliferation. Tetradecanoylphorbol Acetate stathmin 1 Homo sapiens
2 TPA treatment of IL-2-dependent PBL at the peak of their growth caused phosphorylation of about two-thirds of preexisting unphosphorylated prosolin within 1 h. This was accompanied by cessation of cell proliferation, as indicated by measurements of TdR incorporation. Tetradecanoylphorbol Acetate stathmin 1 Homo sapiens
3 It is suggested that increased phosphorylation of prosolin may be an initiating event in the antiproliferative response to TPA, which would occur only in proliferating lymphocytes expressing prosolin. Tetradecanoylphorbol Acetate stathmin 1 Homo sapiens
4 It is suggested that increased phosphorylation of prosolin may be an initiating event in the antiproliferative response to TPA, which would occur only in proliferating lymphocytes expressing prosolin. Tetradecanoylphorbol Acetate stathmin 1 Homo sapiens