Title : In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei.

Pub. Date : 2016 Jul 25

PMID : 27457761






1 Functional Relationships(s)
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1 However, two salinomycin derivatives (salinomycin n-butyl amide and salinomycin 2,2,2-trifluoroethyl ester) were identified that showed increased anti-trypanosomal activity with 50 % growth inhibition values in the mid nanomolar range and minimum inhibitory concentrations of below 1 muM similar to suramin, a drug used in the treatment of sleeping sickness. salinomycin latexin Homo sapiens