Title : p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.

Pub. Date : 2016 Aug 1

PMID : 27454290






2 Functional Relationships(s)
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1 Treatment of pregnant p53d/d mice with either the antidiabetic drug metformin or the antioxidant resveratrol activated AMPK signaling and inhibited mTORC1 signaling in decidual cells. Metformin CREB regulated transcription coactivator 1 Mus musculus
2 Together, these results reveal that p53-dependent coordination of AMPK and mTORC1 signaling controls parturition timing and suggest that metformin and resveratrol have therapeutic potential to prevent PTB. Metformin CREB regulated transcription coactivator 1 Mus musculus