Pub. Date : 2016 Sep 13
PMID : 27449295
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Consistent with SENP1 inhibition, Mc increased SUMOylated protein levels, which was further confirmed by the accumulation of two known SUMOylated proteins, hypoxia inducible factor-1a and nucleus accumbens associated protein 1 in PC3 cells. | Methylcholanthrene | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | Compared to LNCaP and normal prostate epithelial RWPE-1 cells, PC3 cells had higher levels of SENP1 mRNA and were more sensitive to Mc-induced growth inhibition. | Methylcholanthrene | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | Overexpression of SENP1 rescued PC3 cells from Mc-induced apoptosis. | Methylcholanthrene | BTG anti-proliferation factor 2 | Homo sapiens |