Pub. Date : 1989 Mar 29
PMID : 2744079
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [3H]Ro 19-6327: a reversible ligand and affinity labelling probe for monoamine oxidase-B. | Tritium | monoamine oxidase B | Homo sapiens |
| 2 | This compound is a novel, time-dependent inhibitor of monoamine oxidase type B (MAO-B) and is structurally closely related to [3H]Ro 16-6491. | Tritium | monoamine oxidase B | Homo sapiens |
| 3 | This compound is a novel, time-dependent inhibitor of monoamine oxidase type B (MAO-B) and is structurally closely related to [3H]Ro 16-6491. | Tritium | monoamine oxidase B | Homo sapiens |
| 4 | The dissociation rate was markedly decreased (t1/2 = greater than 24h) at 0 degrees C. MAO-B, but not MAO-A inhibitors, effectively prevented the binding of [3H]Ro 19-6327. | Tritium | monoamine oxidase B | Homo sapiens |
| 5 | Like [3H]Ro 16-6491, [3H]Ro 19-6327 is recognized as a substrate by MAO-B, being eventually deaminated by the enzyme. | Tritium | monoamine oxidase B | Homo sapiens |
| 6 | Like [3H]Ro 16-6491, [3H]Ro 19-6327 is recognized as a substrate by MAO-B, being eventually deaminated by the enzyme. | Tritium | monoamine oxidase B | Homo sapiens |
| 7 | Since the deaminated aldehyde derivative of Ro 19-6327 did not inhibit MAO-B, a still unidentified reversible adduct, formed at the MAO-B active site, might explain the high potency and selectivity of [3H]Ro 19-6327. | Tritium | monoamine oxidase B | Homo sapiens |
| 8 | The presence of unlabelled MAO-B inhibitors in the incubation mixture prevented the covalent incorporation of [3H]Ro 19-6327. | Tritium | monoamine oxidase B | Homo sapiens |
| 9 | The irreversible MAO-B inhibitor, [3H] pargyline, labelled a protein with a molecular weight identical to the protein labelled by [3H]Ro 19-6327. | Tritium | monoamine oxidase B | Homo sapiens |