Pub. Date : 2016 Sep 1
PMID : 27425828
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low doses of arsenic, via perturbing p53, promotes tumorigenesis. | Arsenic | tumor protein p53 | Homo sapiens |
| 2 | In this study, we demonstrate that low doses of arsenic exposure mitigate or mask p53 function and further perturb intracellular redox state, which triggers persistent endoplasmic reticulum (ER) stress and activates UPR (unfolded protein response), leading to transformation or tumorigenesis. | Arsenic | tumor protein p53 | Homo sapiens |
| 3 | Thus, the results suggest that low doses of arsenic exposure, through attenuating p53-regulated tumor suppressive function, change the state of intracellular redox and create a microenvironment for tumorigenesis. | Arsenic | tumor protein p53 | Homo sapiens |