Pub. Date : 2016 Sep 9
PMID : 27422604
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2-p53 cascade. | Doxorubicin | microRNA 214 | Homo sapiens |
| 2 | In this study, we report that miR-214 is strikingly down-regulated in breast cancer cell lines and clinical samples, particularly, in the doxorubicin resistant tumor tissues. | Doxorubicin | microRNA 214 | Homo sapiens |
| 3 | Remarkably, restoration of miR-214 expression induces apoptosis and sensitizes the MCF7 cells sustaining wild-type p53, but not the p53 null MDA-MB-157 cells, to doxorubicin. | Doxorubicin | microRNA 214 | Homo sapiens |