Pub. Date : 2016 Oct 1
PMID : 27413196
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | There is increasing evidence that regulation of the cGMP-cGMP-dependent protein kinase 1-phosphodiesterase (cGMP-cGK1-PDE) signaling pathway may be renoprotective. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 2 | This review gives an outline of the cGMP-cGK1-PDE signaling pathways and details the downstream signaling and regulatory functions that are modulated by cGK1 and PDE inhibitors with regard to antifibrotic, antithrombotic, and antitumor activity. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 3 | This review gives an outline of the cGMP-cGK1-PDE signaling pathways and details the downstream signaling and regulatory functions that are modulated by cGK1 and PDE inhibitors with regard to antifibrotic, antithrombotic, and antitumor activity. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 4 | Current evidence that supports the renoprotective effects of regulating cGMP-cGK1-PDE signaling is also summarized. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 5 | We conclude that regulation of cGMP-cGK1-PDE signaling might provide novel, therapeutic strategies for the worsening global public health problem of CKD. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |