Title : Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

Pub. Date : 2016 Jul 14

PMID : 27412403






1 Functional Relationships(s)
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1 Upon BA signalling, RanBP2 co-localizes with SHP at the nuclear envelope region and mediates SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repressive histone modifiers to inhibit BA synthetic genes. Bile Acids and Salts small ubiquitin-like modifier 2 Mus musculus