Pub. Date : 2016
PMID : 27404728
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. | Selenium | selenium binding protein 1 | Homo sapiens |
| 2 | Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. | Selenium | selenium binding protein 1 | Homo sapiens |
| 3 | Because genome instability is a hallmark of cancer, we hypothesize that SBP1 sequesters cellular selenium and sensitizes cancer cells to DNA-damaging agents. | Selenium | selenium binding protein 1 | Homo sapiens |
| 4 | Reduced sensitivity to hydrogen peroxide, paraquat and camptothecin, reactive oxygen species content, and intracellular retention of selenium after selenomethionine treatment were observed in SBP1 shRNA HeLa cells. | Selenium | selenium binding protein 1 | Homo sapiens |
| 5 | Altogether, SBP1 retains supplemental selenium and sensitizes HeLa cancer cells to clastogens, suggesting a new cancer treatment strategy by sequestering selenium through SBP1. | Selenium | selenium binding protein 1 | Homo sapiens |
| 6 | Altogether, SBP1 retains supplemental selenium and sensitizes HeLa cancer cells to clastogens, suggesting a new cancer treatment strategy by sequestering selenium through SBP1. | Selenium | selenium binding protein 1 | Homo sapiens |