Title : Effects of ceftaroline on the innate immune and on the inflammatory responses of bronchial epithelial cells exposed to cigarette smoke.

Pub. Date : 2016 Sep 6

PMID : 27397760






3 Functional Relationships(s)
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1 Ceftaroline counteracted the CSE effect on TLR2 expression, on LPS binding, on IL-8 mRNA, HBD2 and NFkB in 16HBE. T 91825 defensin beta 4A Homo sapiens
2 The effects of ceftaroline on HBD2 protein and on IL-8 mRNA were confirmed in primary bronchial epithelial cells. T 91825 defensin beta 4A Homo sapiens
3 In conclusion, ceftaroline is able to counteract the effects of CSE on the innate immunity and pro-inflammatory responses modulating TLR2, LPS binding, NFkB activation and activity, HBD2 and IL-8 expression in bronchial epithelial cells. T 91825 defensin beta 4A Homo sapiens