Title : Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.

Pub. Date : 2016 Oct 4

PMID : 27392529






1 Functional Relationships(s)
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1 AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). Aminosalicylic Acid acetylcholinesterase (Cartwright blood group) Homo sapiens