Title : Effect of NADPH-cytochrome P450 reductase on all-trans-retinoic acid efficacy and cytochrome P450 26A1 expression in human myeloid leukaemia HL-60 cells.

Pub. Date : 2016 Sep

PMID : 27366899






2 Functional Relationships(s)
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Protein Name
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1 Cytochrome P450 oxidoreductase (POR) is the only obligate electron donor for all of the microsomal cytochrome P450 enzymes including CYP26A1 which is highly specific for ATRA metabolism and efficacy in human myeloid leukaemia cells. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
2 KEY FINDINGS: All-trans-retinoic acid treatment caused the expression of POR upregulation and CYP26A1 downregulation in dose- and time-dependent manners. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens