Pub. Date : 2016 Jun 28
PMID : 27353420
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models. | venetoclax | B cell leukemia/lymphoma 2 | Mus musculus |
2 | BACKGROUND: Venetoclax, a small molecule BH3 mimetic which inhibits the anti-apoptotic protein Bcl-2, and idasanutlin, a selective MDM2 antagonist, have both shown activity as single-agent treatments in pre-clinical and clinical studies in acute myeloid leukemia (AML). | venetoclax | B cell leukemia/lymphoma 2 | Mus musculus |