Title : Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.

Pub. Date : 2016 Sep 1

PMID : 27335171






1 Functional Relationships(s)
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1 We report here that inhibition of V-ATPase with bafilomycin A1 as well as inactivation of the GTP-GDP cycle of Rab5a GTPase phenotypically rescued or completely precluded the cytoplasmic vacuolization despite the continued presence of inactivated PIKfyve or Vps34. Guanosine Diphosphate RAB5A, member RAS oncogene family Homo sapiens