Title : Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin.

Pub. Date : 2016 Aug 1

PMID : 27335167






1 Functional Relationships(s)
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1 The inhibitory effect of simvastatin on atrial fibroblasts was abrogated by mevalonic acid (500 muM) that bypasses 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition. Simvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens