Title : Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin.

Pub. Date : 1989 Mar

PMID : 2732208






3 Functional Relationships(s)
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1 One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group. N-Acetylneuraminic Acid chorionic gonadotropin subunit beta 5 Homo sapiens
2 One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group. N-Acetylneuraminic Acid chorionic gonadotropin subunit beta 5 Homo sapiens
3 In order to determine whether this sialic acid linkage is important for the functional role played by the sugar moiety of hCG or not, isomeric hCG containing the Neu5Ac alpha 2----6Gal group was prepared and its hormonal activity in vitro was investigated. N-Acetylneuraminic Acid chorionic gonadotropin subunit beta 5 Homo sapiens