Title : Mechanisms of BDNF regulation in asthmatic airway smooth muscle.

Pub. Date : 2016 Aug 1

PMID : 27317689






1 Functional Relationships(s)
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1 We find that TNF-alpha enhances BDNF release by ASM cells, via several mechanisms relevant to asthma, including transient receptor potential channels TRPC3 and TRPC6 (but not TRPC1), ERK 1/2, PI3K, PLC, and PKC cascades, Rho kinase, and transcription factors cAMP response element binding protein and nuclear factor of activated T cells. Cyclic AMP tumor necrosis factor Homo sapiens