Title : N'-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFκB/IL-6/STAT3 pathway.

Pub. Date : 2016 Aug 19

PMID : 27311853






2 Functional Relationships(s)
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1 In this study, we discovered the inhibitory activity of the polyphenol compound (1) in DSS induced colitis in mice by targeting NFkappaB/IL-6/STAT3 pathway. Polyphenols signal transducer and activator of transcription 3 Mus musculus
2 Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 and Bax. Polyphenols signal transducer and activator of transcription 3 Mus musculus