Title : Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

Pub. Date : 2016 Jun 28

PMID : 27298364






1 Functional Relationships(s)
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1 Systemic administration of the high-affinity Sig1R ligand (+)-pentazocine [(+)-PTZ] to rd10 mice over several weeks led to the rescue of cone function as indicated by electroretinographic recordings using natural noise stimuli and preservation of cone cells upon spectral domain optical coherence tomography and retinal histological examination. Pentylenetetrazole phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Mus musculus