Title : Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.

Pub. Date : 2016 Jun 11

PMID : 27294910






1 Functional Relationships(s)
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1 Using the chemically synthesized oligonucleotides, we investigated the excision of the 3"-CTNAs in DNA by the human excision repair cross complementing protein 1-xeroderma pigmentosum group F (ERCC1-XPF) endonuclease, which is one of the main components of the nucleotide excision repair pathway. Oligonucleotides ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens