Title : Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration.

Pub. Date : 2016 Jul

PMID : 27270966






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1 Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration. Bleomycin periostin, osteoblast specific factor Mus musculus
2 Here, we show that the ECM architecture organized by periostin, a matricellular protein, plays a pivotal role in the survival of bleomycin-exposed mice. Bleomycin periostin, osteoblast specific factor Mus musculus
3 Although periostin-null mice displayed no significant difference in lung histology and air-blood permeability, they exhibited early lethality in a model of bleomycin-induced lung injury, compared with their wild-type counterparts. Bleomycin periostin, osteoblast specific factor Mus musculus
4 This early lethality may have been due to increased pulmonary leakage of blood fluid into the air space in the bleomycin-exposed periostin-null mice. Bleomycin periostin, osteoblast specific factor Mus musculus