Pub. Date : 2017 Feb
PMID : 27270636
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. | Ethanol | tumor protein p53 | Homo sapiens |
| 2 | This study was designed to test the hypothesis that Siah1 mediates ethanol-induced apoptosis in NCCs through p38 MAPK-mediated activation of the p53 signaling pathway. | Ethanol | tumor protein p53 | Homo sapiens |
| 3 | We found that exposure of NCCs to ethanol resulted in the increases in the total protein levels of p53 and the phosphorylation of p53 at serine 15. | Ethanol | tumor protein p53 | Homo sapiens |
| 4 | We found that exposure of NCCs to ethanol resulted in the increases in the total protein levels of p53 and the phosphorylation of p53 at serine 15. | Ethanol | tumor protein p53 | Homo sapiens |
| 5 | Knock-down of Siah1 by siRNA or down-regulation of p38 MAPK by either siRNA or inhibitor significantly diminished ethanol-induced accumulations of p53 and the phosphorylation of p53. | Ethanol | tumor protein p53 | Homo sapiens |
| 6 | Knock-down of Siah1 by siRNA or down-regulation of p38 MAPK by either siRNA or inhibitor significantly diminished ethanol-induced accumulations of p53 and the phosphorylation of p53. | Ethanol | tumor protein p53 | Homo sapiens |
| 7 | In addition, ethanol exposure resulted in a significant increase in the expression of p53 downstream targets and apoptosis in NCCs, which can be significantly diminished by down-regulation of Siah1 with siRNA. | Ethanol | tumor protein p53 | Homo sapiens |
| 8 | These results demonstrate that Siah1 plays a crucial role in ethanol-induced apoptosis in NCCs, and that the up-regulation of Siah1 by ethanol can trigger apoptosis through p38 MAPK-mediated activation of the p53 signaling pathway. | Ethanol | tumor protein p53 | Homo sapiens |
| 9 | These results demonstrate that Siah1 plays a crucial role in ethanol-induced apoptosis in NCCs, and that the up-regulation of Siah1 by ethanol can trigger apoptosis through p38 MAPK-mediated activation of the p53 signaling pathway. | Ethanol | tumor protein p53 | Homo sapiens |