Title : Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo.

Pub. Date : 2016 Jun 28

PMID : 27259258






1 Functional Relationships(s)
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1 Sorafenib/pazopanib combined with sildenafil in a [GRP78+HSP27] -dependent fashion to: (i) profoundly activate an eIF2alpha/Beclin1 pathway; (ii) profoundly inactivate mTOR and increase ATG13 phosphorylation, collectively resulting in the formation of toxic autophagosomes. Sorafenib heat shock protein family B (small) member 1 Homo sapiens