Title : Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells.

Pub. Date : 2016 Sep

PMID : 27256378






1 Functional Relationships(s)
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1 Importantly, inhibition of BTK prevents activation of the AKT signaling pathway by NRG or EGF that has been shown to promote growth factor-driven lapatinib resistance in HER2(+) breast cancer cells. Lapatinib AKT serine/threonine kinase 1 Homo sapiens