Title : Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast cancer cells.

Pub. Date : 1989 Apr

PMID : 2725533






3 Functional Relationships(s)
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1 In addition, 1 nM E2 inhibited the marked stimulation induced by 1 nM DHT or 300 nM DEX on GCDFP-15 mRNA accumulation and on the secretion of the glycoprotein. Dihydrotestosterone prolactin induced protein Homo sapiens
2 However, at the concentration used, E2 reversed by only 65% the stimulation achieved by the combination of DHT and DEX on GCDFP-15 mRNA levels. Dihydrotestosterone prolactin induced protein Homo sapiens
3 It is of interest to mention that the effect of DHT, DEX, and E2 on GCDFP-15 expression is opposite to the respective effect of each steroid on ZR-75-1 cell proliferation. Dihydrotestosterone prolactin induced protein Homo sapiens