Title : Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.

Pub. Date : 1989 May

PMID : 2725472






1 Functional Relationships(s)
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1 Various 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) cause mechanism-based inactivation of cytochrome P-450 (P-450) by destroying the heme prosthetic group. Zalcitabine cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus