Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

Pub. Date : 2016 Aug

PMID : 27230386






1 Functional Relationships(s)
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1 Collectively, these results suggest that the design and investigation of multifunctional agents containing along with the acetylcholinesterase inhibitory segment also an antioxidant moiety capable of alleviating metal (copper)-induced oxidative stress, may be of importance in the treatment of Alzheimer"s disease. Copper acetylcholinesterase (Cartwright blood group) Homo sapiens