Title : Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-Reductase Inhibition in Prostate Epithelial Cells.

Pub. Date : 2016 Jul 8

PMID : 27226548






1 Functional Relationships(s)
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1 Dutasteride also induces cyclooxygenase type 2 (COX-2), which functions in a negative feedback loop in TGFbeta and ERbeta signaling pathways as evidenced by the potentiation of apoptosis induced by dutasteride or finasteride upon pharmacological inhibition or shRNA-mediated ablation of COX-2. Finasteride transforming growth factor beta 1 Homo sapiens