Pub. Date : 2017 Jan
PMID : 27222231
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, LY294002 inhibited 17beta-estradiol-induced activation of Akt. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | PI3K/Akt Activated by GPR30 and Src Regulates 17beta-Estradiol-Induced Cultured Immature Boar Sertoli Cells Proliferation. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In the present study, the role of PI3K/Akt on the 17beta-estradiol-induced piglet SC proliferation was explored. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | We also found that 17beta-estradiol induced activation of Akt in a time-dependent manner. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Both LY294002 (an inhibitor of PI3K) and 10-DEBC (an inhibitor of Akt) significantly reduced 17beta-estradiol-induced SC proliferation and reduced mRNA and protein expression of Skp2. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | The results indicated that 17beta-estradiol regulates SC proliferation by activating PI3K/Akt. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | Both GPR30 and Src are involved in 17beta-estradiol-induced phosphorylation of PI3K/Akt. | Estradiol | AKT serine/threonine kinase 1 | Homo sapiens |