Pub. Date : 2017 Jan
PMID : 27222231
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PI3K/Akt Activated by GPR30 and Src Regulates 17beta-Estradiol-Induced Cultured Immature Boar Sertoli Cells Proliferation. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 2 | Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2). | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |
| 3 | Both GPR30 and Src are involved in 17beta-estradiol-induced phosphorylation of PI3K/Akt. | Estradiol | G protein-coupled estrogen receptor 1 | Homo sapiens |