Title : Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

Pub. Date : 2016 Jun 23

PMID : 27213719






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compounds 3, 4, and 6-9 circumvented Pgp and betaIII-tubulin mediated drug resistance, mechanisms that can limit the efficacy of paclitaxel, docetaxel, and the vinca alkaloids. Docetaxel phosphoglycolate phosphatase Homo sapiens