Pub. Date : 2016 Aug
PMID : 27208893
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | Some natural steroids such as gitogenin, tigogenin, and solasodine were found to be the novel selective inhibitors of UGT1A4, and did not inhibit the activities of major human CYP isoforms. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | And this inhibition of steroids towards UGT1A4 was also verified in human primary hepatocytes. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 4 | Furthermore, a quantitative structure-activity relationship (QSAR) of steroids with inhibitory effects toward human UGT1A4 isoform was established using the computational methods. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 5 | Our findings elucidate the potential for in vivo HDI effects of steroids in herbal medicine and foods, with the clinical dr ugs eliminated by UGT1A4, and reveal the vital pharamcophoric requirement of natural steroids for UGT1A4 inhibition activity. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 6 | Our findings elucidate the potential for in vivo HDI effects of steroids in herbal medicine and foods, with the clinical dr ugs eliminated by UGT1A4, and reveal the vital pharamcophoric requirement of natural steroids for UGT1A4 inhibition activity. | Steroids | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |