Title : Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal.

Pub. Date : 2016 Jul

PMID : 27207515






7 Functional Relationships(s)
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1 Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. Glucose apolipoprotein A-I Mus musculus
2 ApoA-I also provides glucose control with described in vitro effects of apoA-I on beta-cell insulin secretion and muscle glucose uptake. Glucose apolipoprotein A-I Mus musculus
3 ApoA-I also provides glucose control with described in vitro effects of apoA-I on beta-cell insulin secretion and muscle glucose uptake. Glucose apolipoprotein A-I Mus musculus
4 In addition, apoA-I injections in insulin-resistant diet-induced obese (DIO) mice lead to increased glucose-stimulated insulin secretion (GSIS) and peripheral tissue glucose uptake. Glucose apolipoprotein A-I Mus musculus
5 In addition, apoA-I injections in insulin-resistant diet-induced obese (DIO) mice lead to increased glucose-stimulated insulin secretion (GSIS) and peripheral tissue glucose uptake. Glucose apolipoprotein A-I Mus musculus
6 Data demonstrate that apoA-I to an equal extent enhances GSIS and acts as peripheral tissue activator of insulin-independent glucose uptake and verify skeletal muscle as an apoA-I target tissue. Glucose apolipoprotein A-I Mus musculus
7 Intriguingly, our analyses also identify the heart as an important target tissue for the apoA-I-stimulated glucose uptake, with potential implications in diabetic cardiomyopathy. Glucose apolipoprotein A-I Mus musculus