Title : Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes.

Pub. Date : 2016 Aug

PMID : 27207509






1 Functional Relationships(s)
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1 We extend this work to show that in addition to matrix metalloproteinase 9, hypoxia-inducible factor 1alpha, and cleaved AMPKalpha, patient leukocytes also express IRS-1 phosphorylated on Ser(312), Akt phosphorylated on Thr(308), and elevated TLR4 expression. Serine insulin receptor substrate 1 Homo sapiens