Title : Multigene and Drug Interaction Approach for Tamoxifen Metabolite Patterns Reveals Possible Involvement of CYP2C9, CYP2C19, and ABCB1.

Pub. Date : 2016 Dec

PMID : 27198207






2 Functional Relationships(s)
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Protein Name
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1 Lower concentrations of endoxifen and endoxifen/4-hydroxytamoxifen ratios were seen with impaired CYP2C9 (P = .05 and P = .03, respectively) if patients had the same CYP2D6 phenotype and were not taking a CYP2D6 or CYP2C19 inhibitor. hydroxytamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 Lower concentrations of endoxifen and endoxifen/4-hydroxytamoxifen ratios were seen with impaired CYP2C9 (P = .05 and P = .03, respectively) if patients had the same CYP2D6 phenotype and were not taking a CYP2D6 or CYP2C19 inhibitor. hydroxytamoxifen cytochrome P450 family 2 subfamily D member 6 Homo sapiens