Pub. Date : 2016 May 1
PMID : 27197267
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The BRCA1-Delta11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin. | Cisplatin | BRCA1 DNA repair associated | Homo sapiens |
| 2 | CRISPR/Cas9 gene editing as well as overexpression experiments revealed that the BRCA1-Delta11q protein was capable of promoting partial PARPi and cisplatin resistance relative to full-length BRCA1, both in vitro and in vivo Furthermore, spliceosome inhibitors reduced BRCA1-Delta11q levels and sensitized cells carrying exon 11 mutations to PARPi treatment. | Cisplatin | BRCA1 DNA repair associated | Homo sapiens |