Pub. Date : 2016 Jun 15
PMID : 27197028
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The current study evaluated whether the antinociceptive effect of lycopene is mediated through the modulation of Cx43 expression in spinal astrocytes. | Lycopene | gap junction protein, alpha 1 | Mus musculus |
| 2 | The effect of intrathecal lycopene on Cx43 expression and neuropathic pain were evaluated in mice with partial sciatic nerve ligation (PSNL). | Lycopene | gap junction protein, alpha 1 | Mus musculus |
| 3 | In addition, repeated, but not single, intrathecal treatment with lycopene of mice with a partial sciatic nerve ligation significantly prevented not only the downregulation of Cx43 expression in spinal dorsal horn but mechanical hypersensitivity as well. | Lycopene | gap junction protein, alpha 1 | Mus musculus |
| 4 | SIGNIFICANCE: The current findings suggest a significant spinal mechanism that mediates the analgesic effect of lycopene, through the restoration of normal spinal Cx43 expression. | Lycopene | gap junction protein, alpha 1 | Mus musculus |