Title : Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations.

Pub. Date : 2016 Jul 26

PMID : 27191893






1 Functional Relationships(s)
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1 However, when stratified by chemotherapy regimen, patients whose tumors had TP53 and HR mutations demonstrated a marked survival advantage when treated with platinum and paclitaxel vs. platinum +/- cyclophosphamide (median OS of 90 months (95% CI 50-NA) vs. 29.5 months (95% CI 17.7-50.5), p = 0.0005). Paclitaxel tumor protein p53 Homo sapiens