Title : Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles.

Pub. Date : 2016 May 12

PMID : 27190598






1 Functional Relationships(s)
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1 Generation of a library of molecules resulted in the identification of the most selective inhibitor of SphK1 reported to date (705-fold selectivity over SphK2), and we found that potency and selectivity vary significantly depending on the particular oxadiazole isomer employed. Oxadiazoles sphingosine kinase 1 Homo sapiens