Title : Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial.

Pub. Date : 2016 Aug 8

PMID : 27189318






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RESULTS: Baseline and 24-month levels of monocyte chemotactic protein-1-to-creatinine ratio levels were higher for cases versus controls. Creatinine C-C motif chemokine ligand 2 Homo sapiens
2 The highest quartile of baseline monocyte chemotactic protein-1-to-creatinine ratio had fivefold greater odds, and each log increment had 2.27-fold higher odds for outcome (odds ratio, 5.27; 95% confidence interval, 2.19 to 12.71 and odds ratio, 2.27; 95% confidence interval, 1.44 to 3.58, respectively). Creatinine C-C motif chemokine ligand 2 Homo sapiens
3 C statistic for traditional predictors of eGFR decline was 0.70, which improved significantly to 0.74 with monocyte chemotactic protein-1-to-creatinine ratio. Creatinine C-C motif chemokine ligand 2 Homo sapiens
4 CONCLUSIONS: Urinary monocyte chemotactic protein-1-to-creatinine ratio concentrations were strongly associated with sustained renal decline in patients with type 2 diabetes with preserved renal function. Creatinine C-C motif chemokine ligand 2 Homo sapiens