Pub. Date : 2016 May 16
PMID : 27184800
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib. | Sorafenib | metallothionein 1G | Homo sapiens |
| 2 | RESULTS: We observed that genes of the metallothionein-1 (MT1) family are induced in the HCC cell line Huh7 exposed to sorafenib. | Sorafenib | metallothionein 1G | Homo sapiens |
| 3 | RESULTS: We observed that genes of the metallothionein-1 (MT1) family are induced in the HCC cell line Huh7 exposed to sorafenib. | Sorafenib | metallothionein 1G | Homo sapiens |
| 4 | Sorafenib increased the expression of MT1G mRNA in a panel of human cancer cells, an effect that was not observed with eight other clinically-approved kinase inhibitors. | Sorafenib | metallothionein 1G | Homo sapiens |
| 5 | We identified the minimal region of the MT1G promoter that confers inducibility by sorafenib to a 133 base pair region containing an Anti-oxidant Response Element (ARE) and showed the essential role of the transcription factor NRF2 (Nuclear factor erythroid 2-Related Factor 2). | Sorafenib | metallothionein 1G | Homo sapiens |
| 6 | Finally, we showed that the protein levels of MT1 increase in the serum of some HCC patients receiving sorafenib, and found an association with reduced overall survival. | Sorafenib | metallothionein 1G | Homo sapiens |
| 7 | CONCLUSION: These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells. | Sorafenib | metallothionein 1G | Homo sapiens |