Title : Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.

Pub. Date : 2016 Jun 15

PMID : 27179975






1 Functional Relationships(s)
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1 In vivo, the PPARbeta/delta agonist GW0742 treatment prevented the LPS-induced reduction in aortic relaxation, the increase in vascular ROS production, the upregulation of NOX1, NOX2, p47(phox), and p22(phox) mRNA levels, and the endoplasmic reticulum (ER) stress markers in mice. GW0742 NADPH oxidase 1 Mus musculus