Title : The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

Pub. Date : 2016 Aug

PMID : 27178323






3 Functional Relationships(s)
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1 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
2 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus
3 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus